New Bioactive Ligand and Its Ni(Ⅱ) and Cu(Ⅱ) Complexes: Synthetic Preparation, Spectroscopic Characterization and Biological Evaluation

Abstract

Bioactive ligands are a large range of compounds that are identified by the involvement of a double bond between the C and N atoms. Their versatility stems from combining them with different aryl or alkyl substituents. These kinds of compounds are produced in the lab and occur naturally. For many years, chemists and biochemists have found great inspiration in bioactive ligands. In order to highlight the significance of bioactive ligands, this study offers a new perspective on this class of chemicals in this article. A new bioactive ligand 2-((5-bromo-2-methoxybenzylidene) amino)-6-choloro-4-nitrophenol (L) were synthesized from 5-bromo-2-methoxybenzaldehyde and 2-Amino-6-chloro-4-nitrophenol. Corresponding mononuclear Ni(Ⅱ) and Cu(Ⅱ) complexes were synthesized and spectrochemically characterized by FT-IR, NMR, UV-visible, ESI-MS, Thermogravimetric analysis (TGA) and cyclic voltammetry (CV). The band appearance at 1668 cm^-1 is assigned to azomethine ʋ(C=N), which moves towards a lesser frequency region for both the metal complexes. The CV suggests a quasi-reversible one-electron transfer reaction. Metal complexes show six-coordinate distorted octahedral geometry. All the complexes are completely soluble in DMSO and DMF. Bioactive ligands and their metal complexes are biologically active. Metal complex Cu (Ⅱ) shows better biomedical applications i.e., antifungal at 75% concentration and antibacterial at 50% concentration.