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Eco-friendly and highly efficient multigram synthesis of 3-chloro-1,2-propanediol using sonochemistry

Ligia Souza da Silveira Pinto, Emerson Teixeira da Silva, Marcus Vinicius Nora de Souza


A new short, simple, green and an inexpensive industrially practical process for the preparation of 3-chloro-1,2-propanediol was developed by using ultrasound irradiation avoiding the use of solvents, of acidic or basic conditions. The only reagent used is water and no waste is generated. Optimal conditions and yield (82%) were obtained by using 2.2 molar equivalents of water at 90 W for 1 hr.

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