Chemical Synthesis Strategies for Thiohydantoin Derivatives: A Comprehensive Review
Abstract
The synthesis of 2-thiohydantoin derivatives has been explored through both classical and modern methodologies. In this sulfur-containing analog of hydantoin, one or both carbonyl groups are substituted with thiocarbonyl moieties. This study reviews a broad spectrum of synthetic approaches, including traditional methods such as theorema and reactions involving amino acids, as well as advanced techniques like microwave-assisted synthesis. Furthermore, various reaction mechanisms and the resulting thiohydantoin derivatives are thoroughly illustrated.
Published
29-09-2025
Issue
Section
Organic Chemistry
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