Synthesis, structural characterization and antibacterial activity of Co (II)- complex of 2-acetoxy benzene carboxylic acid
DOI:
https://doi.org/10.13171/mjc02503191820huseinovićAbstract
Metal complexes are gaining more and more importance, especially in the design of drugs in coordination with metal. This has led to numerous studies on metal drug complexes that have been shown to be effective in the treatment of various diseases caused by viruses as well as in the treatment of cancer. A complex of cobalt(II) with the nonsteroidal anti-inflammatory drug 2-acetoxy benzene carboxylic acid was synthesized and characterized by physicochemical and spectroscopic techniques. Experimental data showed that the tested pharmaceutical active substance acts as a bidentate ligand through carbonyl oxygen of carboxyl and ester groups. Screening of antibacterial activity for complex samples was performed by well diffusion assay against six different bacterial strains (E. coli, Staphylococcus aureus, Bacillus subtilis, Listeria monocytogenes, Salmonella Enteritidis and Pseudomonas aeruginosa) and Candida albicans. Research has shown that the complex of 2-acetoxy benzene carboxylic acid with Co (II) ions shows a weak antibacterial and antifungal effect.References
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