Cover Image

Novel Ni(II) and Zn(II) Schiff base metal chelates as promising DNA binder, Antioxidant and Antifungal agents

Anshita Varshney, A. P. Mishra


Schiff base ligands and their 3d-metal chelates have gained significant attention due to various applications in various scientific platforms. Due to their chelating propensity, they possess a wide range of biological, biochemical, catalytic, clinical, dying, and pharmacological properties. Here, in present studies, two novel Ni(II) and Zn(II) transition metal chelates have been synthesized by condensing their metal salts with Schiff base ligand 4-chloro-2-(2,5-dimethoxybenzylideneamino)-5-nitrophenol originated from 2,5-dimethoxybenzaldehyde and 2-amino-4-chloro-5-nitrophenol. The synthesized Schiff base ligand and its metal chelates have been Spectro-chemically examined by FT-IR, UV-Vis absorption spectroscopy, Mass Spectrometry, 1HNMR, Thermogravimetric analysis (TGA) and Powdered-XRD. These compounds are biologically reactive and exhibit antifungal, antioxidant, and DNA-binding activity. The Ni(II) metal chelate gives better biological activity than the Zn(II) metal chelate and parent Schiff base ligand.

Full Text:



A. M. Abu-Dief, N. H. Alotaibi, E. S. Al-Farraj, Hamza A. Qasem, S. Alzahrani, M. K. Mahfouz, A. Abdou, Fabrication, structural elucidation, theoretical, TD-DFT, vibrational calculation and molecular docking studies of some novel adenine imine chelates for biomedical applications, J. Mol. Liq., 2022, 365, 119961.

H. K. Siuki, P. G. Kargar, G. Bagherzade, New Acetamidine Cu(II) Schiff base complex supported on magnetic nanoparticles pectin for the synthesis of triazoles using click chemistry, Sci Rep., 2022, 12, 3771.

A. A. Al-Shamry, M. M. Khalaf, H. M. A. El-Lateef, T. A. Yousef, G. G. Mohamed, K. M. Kamal El-Deen, M. Gouda, A. M. Abu-Dief, Development of New Azomethine Metal Chelates Derived from Isatin: DFT and Pharmaceutical Studies, Materials, 2023, 16.

F. S. Aljohani, O. A. Omran, E. A. Ahmed, E. S. Al-Farraj, E. F. Elkady, A. Alharbi, N. M. El-Metwaly, I. O. Barnawi, A. M. Abu-Dief , Design, structural inspection of new bis(1H-benzo[d]imidazol-2-yl)methanone complexes: Biomedical applications and theoretical implementations via DFT and docking approaches, Inorg. Chem. Commun., 2023, 148, 110331.

A. M. Abu-Dief, Rafat M. El-Khatib, Faizah S. Aljohani, H. A. Al-Abdulkarim, S. Alzahrani, G. El-Sarrag, M. Ismael, Synthesis, structural elucidation, DFT calculation, biological studies and DNA interaction of some aryl hydrazone Cr3+, Fe3+, and Cu2+ chelates, Comp. Biol.Chem., 2022, 97, 107643.

O. Bakhshi, G. Bagherzade, P. G. Kargar, Biosynthesis of Organic Nanocomposite Using Pistacia vera L. Hull: An Efficient Antimicrobial Agent, Bioinorg. Chem. Appl., 2021, 6, 1-18.

P. G. Kargar, G. Bagherzade, H. Beyzaei, S. Arghavani, BioMOF-Mn: An Antimicrobial Agent and an Efficient Nanocatalyst for Domino One-Pot Preparation of Xanthene Derivatives, Inorg. Chem., 2022, 61, 10678–10693.

A. Nameni, G. Bagherzade1, M. Moudi, P. M. Kargar, Examination of the chemical profile of methanolic extract of Agaricus bisporus wild edible mushroom, Zarnagh region (East Azerbaijan province, Iran), J. Hortic. Postharvest Res., 2022, 5, 1-12.

E. Pormohammad, P. G. Kargar, G. Bagherzade, Loading of green-synthesized cu nanoparticles on Ag complex containing 1,3,5-triazine Schiff base with enhanced antimicrobial activities, Sci. Rep., 2023, 13, 20421.

S. Azimi, M. S. Merza, F. Ghasemi, H. A. Dhahi, F. Baradarbarjastehbaf, M. Moosavi, P. M. Kargar, C. Len, Green and rapid and instrumental one-pot method for the synthesis of imidazolines having potential anti-SARS-CoV-2 main protease activity, Sustain. Chem. Pharm. , 2023, 34, 101136.

M. Zubai, M. Sirajuddin, K. Ullah, A. Haider, F. Perveen, I. Hussain, S. Ali, M. N. Tahir, Synthesis, structural peculiarities, theoretical study and biological evaluation of newly designed O-Vanillin based azomethines, J. Mol. Struct., 2020, 1205, 127574,

H. Kargar, M. F. Mehrjardi, K. S. Munawar, Metal complexes incorporating tridentate ONO pyridyl hydrazone Schiff base ligands: Crystal structure, characterization, and applications, Coord. Chem. Rev., 2024, 501, 215587.

A. Varshney, D. Gupta, A. K. Choubey, S. Brahmchari, A. P. Mishra, Novel Schiff base ligand and its Co(II) & Cu(II) Metal complexes: Synthesis, Physicochemical Characterization, DNA Binding, and Antifungal Screening, Mediterr.J. Chem., 2023, 13(3), 219-227.

N. G. Yernale, M. B. H. Mathada, Preparation of octahedral Cu(II), Co(II), Ni(II) and Zn(II) complexes derived from 8-formyl-7-hydroxy-4-methylcoumarin: Synthesis, characterization and biological study, J. Mol. Struct., 2020, 1220, 128659.

P.G. kargar, G. Bagherzade, H. Beyzaei, A porous metal-organic framework (Ni-MOF): An efficient and recyclable catalyst for cascade oxidative amidation of alcohols by amines under ultrasound-irradiations, Mol. Catal., 2022, 526, 112372.

M. Amirnasr, M. Rasouli, K. Mereiter, Copper(I) complexes of new N2S2 donor Schiff-base ligands derived from 1,2-bis-(2-amino-phenylsulfanyl)ethane, Inorganica Chim. Acta, 2013, 404, 230-235.

R. Gup, B. Kirkan, Synthesis and spectroscopic studies of copper(II) and nickel(II) complexes containing hydrazonic ligands and heterocyclic coligand, Spectrochim. Acta A Mol. Biomol., 2005, 62, 1188-1195.

P. G. Kargar, S. Aryanejad, G. Bagherzade, Simple synthesis of the novel Cu-MOF catalysts for the selective alcohol oxidation and the oxidative cross-coupling of amines and alcohols, Applied Organometallic Chemistry, 2020, 12, e5965.

A. U. Rani, N. Sundaraganesan, M. Kurt, M. Cinar, M. Karabacak, FT-IR, FT-Raman, NMR spectra and DFT calculations on 4-chloro-N-methylaniline, Spectrochim. Acta A Mol. Biomol., 2010, 75, 1523-1529.

H. Inac, M. Ashfaq, N. Dege, M. F. Dehnayebi, K. S. Munawar, N. K. Yağcı, E. P. Çınar, M. N. Tahir, Synthesis, Spectroscopic Characterizations, Single Crystal XRD, Supramolecular Assembly Inspection via Hirshfeld Surface Analysis, and DFT Study of a Hydroxy Functionalized Schiff base Cu(II) complex, J. Mol. Struct., 2024, 1295, 136751.

M. Dolaz, V. Mckee, S. Urus, N. Demir, A. E. Sabik, A. Gölcüd, M. Tümer, Synthesis, structural characterization, catalytic, thermal and electrochemical investigations of bidentate Schiff base ligand and its metal complexes, Spectrochim. Acta A Mol. Biomol., 2010, 76, 174-181,

A. Hosseinian, S. Jabbari, H. R. Rahimipour, A. R. Mahjoub, Synthesis and characterization of nano-scale of a new azido Co(II) complex as single and nano-scale crystals: Bithiazole precursor for the preparation of Co3O4 nano-structures, J. Mol. Struct., 2012, 1028, 215-221.

H. Keypour, M. Shayesteh, R. Golbedaghi, A. Chehregani, A. G. Blackman, Synthesis, characterization, and X-ray crystal structures of metal complexes with new Schiff-base ligands and their antibacterial activities, J. Coord. Chem., 2012, 65, 1004-1016.

A. Kose, Synthesis, structural characterization and DNA binding properties of phthalazinylhydrazone-furan and triazolophthalazine-ferrocene compounds, J. Mol. Struct., 2023, 1274, 134471.

J. Saranya, S. J. Klrubavathy, S. Chitra, A. Zarrouk, K. Kalpana, K. Lavanya, B. Ravikiran, Tetradentate Schiff Base Complexes of Transition Metals for Antimicrobial Activity, Arab. J. Sci. Eng., 2020, 6, 1-13.

M. Sirajuddin, S. Ali, M. N. Tahir, Organotin(IV) derivatives based on 2-((2-methoxyphenyl)carbamoyl)benzoic acid: Synthesis, spectroscopic characterization, assessment of antibacterial, DNA interaction, anticancer and antileishmanial potentials, J. Mol. Struct., 2021, 1299, 129600.

I. Ali, L.M.A. Mahmood, T. H. Mehdar, H. Y. Aboul-Enein, M. A. Said, Synthesis, characterization, simulation, DNA binding and anticancer activities of Co(II), Cu(II), Ni(II) and Zn(II) complexes of a Schiff base containing o-hydroxyl group nitrogen ligand, Inorg. Chem. Commun., 2020, 118, 108004.

H. A. Al-Abdulkarim, R. M. El-khatib, F. S. Aljohani, A. Mahran, A. Alharbi, G. A. M. Mersal, N. M. El-Metwaly, A. M. Abu-Dief, Optimization for synthesized quinoline-based Cr3+, VO2+, Zn2+ and Pd2+complexes: DNA interaction, biological assay and in-silico treatments for verification, J. Mol. Liq., 2021, 339, 116797.

A. Varshney, A. P. Mishra, Synthesis, spectral characterization, computational studies, antifungal, DNA interaction, antioxidant and fluorescence property of novel Schiff base ligand and its metal chelates, Spectrochim. Acta A Mol. Biomol., 2023, 297, 122765.

P. G. Kargar, Z. Moodi, G. Bagherzade, F. Nikoomanesh, Synthesis, characterization, and antimicrobial activity of metal complexes derived from Schiff base of quercetin extracted from Origanum vulgare L., Materials Chemistry and Physics, 2024, 317, 129207.

A. M. Abu‐Dief, L. H. Abdel‐Rahman, M. R. Shehata, A. A. Hassan Abdel‐Mawgoud, Novel azomethine Pd (II)‐ and VO (II)‐based metallo‐ pharmaceuticals as anticancer, antimicrobial, and antioxidant agents: Design, structural inspection, DFT investigation, and DNA interaction, J Phys Org Chem., 2019, 12, e4009.

S. A. Noghabi, P. G. Kargar, G. Bagherzade, H. Beyzaei, Comparative study of antioxidant and antimicrobial activity of berberine-derived Schiff bases, nitro-berberine and amino-berberine, Heliyon, 2023, 9, e22783.



  • There are currently no refbacks.

Copyright (c) 2024 Mediterranean Journal of Chemistry