Novel Schiff base ligand and its Co(II) & Cu(II) Metal complexes: Synthesis, Physicochemical Characterization, DNA Binding, and Antifungal Screening

Novel Schiff base ligand and its Co(II) & Cu(II) Metal complexes: Synthesis, Physicochemical Characterization, DNA Binding, and Antifungal Screening

Authors

  • Anshita Varshney Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003 http://orcid.org/0000-0002-0634-3835
  • Deepshikha Gupta Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003
  • Ankit Kumar Choubey Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003
  • Shivanshu Brahmchari Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003
  • A. P. Mishra Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003

DOI:

https://doi.org/10.13171/mjc02306071707vashney

Abstract

A novel Schiff base ligand 4-chloro-2-(2,5-dimethoxybenzylideneamino)-5-nitrophenol derived from 2,5-dimethoxybenzaldehyde and 2-amino-4-chloro-5-nitrophenol. Its Co(II) and Cu(II) transition metal chelates were also synthesized and physicochemically characterized by FT-IR, UV-Vis absorption spectroscopy, Thermogravimetric analysis (TGA), and Electrochemical studies. These compounds are biologically active and exhibit antifungal and DNA-binding activity. The Cu(II) metal complex gives better biological activity than the Co(II) metal complex and parent Schiff base ligand. 

Author Biographies

Anshita Varshney, Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003

Department of Chemistry

Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003

Deepshikha Gupta, Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003

Department of Chemistry

Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003

Ankit Kumar Choubey, Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003

Department of Chemistry

Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003

Shivanshu Brahmchari, Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003

Department of Chemistry

Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003

A. P. Mishra, Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003

Department of Chemistry

Dr. Hari Singh Gour Vishwavidyalaya (A Central University), Sagar, M.P.-470003

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Published

07-06-2023

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Coordination Chemistry
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