Glycyrrhetinic amides and their cytotoxicity

Glycyrrhetinic amides and their cytotoxicity

Authors

  • Niels Heise Martin-Luther Universität Halle-Wittenberg
  • Sophie Hoenke Martin-Luther Universität Halle-Wittenberg
  • Ahmed Al-Harrasi University of Nizwa
  • Hans-Peter Deigner Furtwangen University
  • René Csuk Martin-Luther Universität Halle-Wittenberg http://orcid.org/0000-0001-7911-290X

DOI:

https://doi.org/10.13171/mjc02110161595Cesuk

Abstract

3-O-Acetyl-glycyrrhetinic amides were prepared, and sulforhodamine B assays investigated their cytotoxicity. Their cytotoxicity strongly depended on the substitution pattern of the respective compounds. Thereby, an ethylenediamine-derived compound 2 performed the best, acting mainly by apoptosis. As far as heterocyclic amides are concerned, ring enlargement and the replacement of the distal nitrogen invariably led to a more or less complete loss of cytotoxic activity. Thus, the presence of a carbonyl function (C-30) seems necessary for providing significant cytotoxicity.

Author Biography

René Csuk, Martin-Luther Universität Halle-Wittenberg

Organic Chemistry

Head of Department

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Published

16-10-2021

Issue

Vol. 11 No. 3 (2021)

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Medicinal Chemistry

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