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Comparative study between the Titanium Phosphate TiP2O7 and the Phosphate Fertilizers in the catalysis of the Quinazolin-4(3H)-one derivatives synthesis

Youssef Merroun, Soukaina Chehab, Tourya Ghailane, Rachida Ghailane, Said Boukhris, Amina Hassikou, Nouzha Habbadi, Brahim Lakhrissi, Abdelaziz Souizi


A simple and efficient method for the synthesis of quinazolin-4(3H)-one derivatives via condensation of anthranilamide with aromatic aldehyde catalyzed by monoammonium phosphate (MAP), diammonium phosphate (DAP), and triple superphosphate (TSP), were developed.  The modification of these three phosphate fertilizers using titanium tetrachloride (TiCl4) has increased their catalytic efficiency. The prepared titanium phosphate (TiP2O7) was characterized using microscopic and spectroscopic methods, namely X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), and infrared spectroscopy (IR). The TiP2O7 was applied for the first time as a heterogeneous catalyst in quinazolin-4(3H)-ones synthesis. High yields and short reaction times were observed in the determined optimal condition (solvent nature, volume, and catalyst amount). This study shows that the TiP2O7 presents an exciting catalytic activity and long-term durability compared to those of MAP, DAP, and TSP.

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