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Click chemistry approach to a series of calcitriol analogues with heterocyclic side chains

Zoila Gándara, Pedro-Lois Suárez, Alioune Fall, Massène Sène, Ousmane Diouf, Mohamed Gaye, Generosa Gómez, yagamare fall

Abstract


We report a straightforward synthesis of a series of novel calcitriol analogues from vitamin D2with some modification of the procedures described by Calverley and Choudhry. This approach allows the large scale synthesis of a late-stage intermediate common to all the analogues of the series.This intermediate was successfully employed to synthesize a huge number of calcitriol analogues using a “click†chemistry approach. 


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References


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